Contact Guidance of Connective Tissue Fibroblasts on Submicrometer Anisotropic Topographical Cues Is Dependent on Tissue of Origin, β1 Integrins, and Tensin-1 Recruitment

Utilizing repeating groove substrates with periodicities of 600, 900, and 1200 nm, and a 100 nm depth, the authors investigated the roles of integrins αvβ3 and β1 associated adhesions on contact guidance of human gingival and dermal fibroblasts.