CD150-Dependent Hematopoietic Stem Cell Sensing of Brucella Instructs Myeloid Commitment

By using specific genetic tools on both the host and pathogen sides, scientists show that HSC can directly sense B. abortus pathogenic bacteria within the bone marrow via the interaction of the cell surface protein CD150 with the bacterial outer membrane protein Omp25, inducing efficient functional commitment of HSC to the myeloid lineage.