Maternal Diet Alters Long-Term Innate Immune Cell Memory in Fetal and Juvenile Hematopoietic Stem and Progenitor Cells in Nonhuman Primate Offspring

Using nonhuman primate models, researchers showed that maternal Western-style diet (mWSD) exposure was associated with persistent pro-inflammatory phenotypes at the transcriptional, metabolic, and functional levels in bone marrow-derived macrophages (BMDMs) from 3-year-old juvenile offspring and in hematopoietic stem and progenitor cells (HSPCs) from fetal and juvenile bone marrow and fetal liver.