Modelling the Erythroblastic Island Niche of Dyserythropoietic Anemia Type IV Patients Using Induced Pluripotent Stem Cells

Investigators showed data that supported the notion that the clinically significant effects of the KLF1-E325K mutation were primarily associated with deficiencies in the erythroid lineage but it is possible that deficiencies in the niche might have the potential to exacerbate the condition.