Phosphorylation and Stabilization of EZH2 by DCAF1/VprBP Trigger Aberrant Gene Silencing in Colon Cancer

Scientists demonstrated that DDB1 and CUL4 Associated Factor 1 (DCAF1) phosphorylated enhancer of Zeste Homolog 2 (EZH2) at T367 to augment its nuclear stabilization and enzymatic activity in colon cancer cells.