Microbiota-Derived Tryptophan Metabolites Indole-3-Lactic Acid Is Associated with Intestinal Ischemia/Reperfusion Injury via Positive Regulation of YAP and Nrf2

Immunofluorescence, quantitative RT-PCR, Western blot, and ELISA were performed to explore the inflammation protective mechanism of tryptophan metabolites in wildtype and Nrf2-deficient mice undergoing intestinal ischemia/reperfusion, hypoxia-reoxygenation induced intestinal organoids.