Anti-Cancer Pro-Inflammatory Effects of an IgE Antibody Targeting the Melanoma-Associated Antigen Chondroitin Sulfate Proteoglycan 4 (CSPG4)

The authors engineered a monoclonal immunoglobin (Ig) E antibody with human constant domains recognizing CSPG4 to target melanoma. CSPG4 IgE bound to human melanomas including metastases, mediated tumoricidal antibody-dependent cellular cytotoxicity, and stimulated human IgE Fc-receptor-expressing monocytes towards pro-inflammatory phenotypes.