The SARS-CoV-2 Papain-Like Protease Suppresses Type I Interferon Responses by Deubiquitinating STING

Scientists investigated the mechanism by which the SARS-CoV-2 papain-like protease (PLpro) antagonizes cellular antiviral response and revealed how SARS-CoV-2 PLpro inhibited type I interferon signaling through stimulator of interferon genes (STING) deubiquitination.