Dynamic Chromatin Accessibility Licenses STAT5- and STAT6-Dependent Innate-Like Function of TH9 Cells to Promote Allergic Inflammation

The authors found that resting TH9 cells produced IL-9 independently of T cell receptor restimulation, due to STAT5- and STAT6-dependent bystander activation. This mechanism was seen in circulating cells from allergic patients and was restricted to recently activated cells.