Cytokinopathy wth Aberrant Cytotoxic Lymphocytes and Profibrotic Myeloid Response in SARS-CoV-2 mRNA Vaccine–Associated Myocarditis

Deep immune profiling using single-cell RNA and repertoire sequencing of peripheral blood mononuclear cells during acute disease revealed expansion of activated CXCR3+ cytotoxic T cells and natural killer cells, both phenotypically resembling cytokine-driven killer cells.