Optimized Spirooxindole-Pyrazole Hybrids Targeting the p53-MDM2 Interplay Induce Apoptosis and Synergize With Doxorubicin in A549 Cells

Researchers introduced a new series of spirooxindoles via hybridization of the chemically stable core spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one and the pyrazole motif inspired by lead pyrazole-based p53 activators, the MDM2 inhibitor.