A Computationally Designed ACE2 Decoy Has Broad Efficacy against SARS-CoV-2 Omicron Variants and Related Viruses In Vitro and In Vivo

Using a computational design strategy, investigators designed an affinity-enhanced ACE2 decoy, FLIF, that exhibited tight binding to SARS-CoV-2 delta and omicron variants, and experimental findings suggested that moving forward, affinity-enhanced ACE2 decoys like FLIF may be required to combat evolving SARS-CoV-2 variants.