DAB2IP Is a Bifunctional Tumor Suppressor That Regulates Wild-Type RAS and Inflammatory Cascades in KRAS Mutant Colon Cancer

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Scientists reported that DAB2IP was mutated or selectively silenced in the vast majority of KRAS and BRAF mutant colorectal cancers. DAB2IP loss promoted tumor development by activating wild-type H- and N-RAS proteins.
[Cancer Research]
AbstractGraphical Abstract