PHGDH Preserves One-Carbon Cycle to Confer Metabolic Plasticity in Chemoresistant Gastric Cancer during Nutrient Stress

Investigators showed that stem-like/epithelial-to-mesenchymal transition/mesenchymal (SEM)-type gastric cancer (GC) exhibited a distinct metabolic profile characterized by high glutaminase levels. SEM-type GC cells were resistant to glutaminolysis inhibition.