PHGDH Preserves One-Carbon Cycle to Confer Metabolic Plasticity in Chemoresistant Gastric Cancer during Nutrient Stress

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Investigators showed that stem-like/epithelial-to-mesenchymal transition/mesenchymal (SEM)-type gastric cancer (GC) exhibited a distinct metabolic profile characterized by high glutaminase levels. SEM-type GC cells were resistant to glutaminolysis inhibition.
[Proceedings Of The National Academy Of Sciences Of The United States Of America]
Abstract