SUMO1 Degrader Induces ER Stress and ROS Accumulation through deSUMOylation of TCF4 and Inhibition of Its Transcription of StarD7 in Colon Cancer

Researchers showed that both StAR-related lipid transfer domain containing 7 (StarD7) mRNA and protein were overexpressed in human colon cancer and its knockout significantly reduced colon cancer cell growth and xenograft progression.