MicroRNA-122-Functionalized DNA Tetrahedron Stimulate Hepatic Differentiation of Human Mesenchymal Stem Cells for Acute Liver Failure Therapy

Scientists demonstrated that the tetrahedral DNA nanoplatform had great potential in inducing the differentiation of human MSCs into functional hepatocyte-like cells by transferring the liver-specific miR122 to hMSCs efficiently without any extrinsic factors.