Repression of TRIM13 by Chromatin Assembly Factor CHAF1B Is Critical for AML Development

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Scientists analyzed RNAseq from mouse MLL-AF9 leukemic cells and bone marrow aspirates representing a diverse collection of pediatric AML samples and identified the E3 ubiquitin ligase TRIM13 as a target of CHAF1B-mediated transcriptional repression associated with leukemogenesis.
[Blood Advances]
Abstract