Phenotypic Diversity of T Cells in Human Primary and Metastatic Brain Tumors Revealed by Multiomic Interrogation
To interrogate potential roles of T cells in this process, the authors profiled these cells from individuals with primary or metastatic brain cancers via integrated analyses on the single-cell and bulk population levels.
[Science Advances] Scientists used single-nucleus RNA sequencing to characterize a mouse model that mimicked human nonalcoholic steatohepatitis (NASH)–driven HCC, the MUP-uPA mouse fed a high-fat diet.
[JHEP Reports] Mouse liver perfusion was used to identify the effects of interstitial flow on hepatocyte proliferation ex vivo. Isolated hepatocytes in vitro were further exposed to varied shear stresses directly.
[JHEP Reports] Cholangiocarcinoma (CCA) tumor microenvironment was recapitulated on a microfluidic three-channel chip using primary CCA cells, cancer-associated fibroblasts, endothelial cells, and T cells isolated from CCA specimens.