An mRNA-Based T Cell-Inducing Antigen Strengthens COVID-19 Vaccine against SARS-CoV-2 Variants
Investigators developed a lipid nanoparticle-formulated mRNA-based T cell-inducing antigen, which targeted three SARS-CoV-2 proteome regions that enriched human HLA-I epitopes.
[EMBO Journal] Using a variety of in vitro and in vivo techniques, researchers showed that metastatic prostate cancer cells acquire a specific Na+/Ca2+ signature required for persistent invasion.
[Molecular Cell] Investigators explored the role of minor intron-containing genes and minor spliceosome in cancer, taking prostate cancer as an exemplar.
[Nature Communications] The authors uncovered dual-phosphorylated form of sterol regulatory element-binding protein 1 (SREBF1), pY673/951-SREBF1 that acts as an androgen sensor, and dissociates from androgen receptor in androgen deficient environment, followed by nuclear translocation.