Hyperglycemia and O-GlcNAc Transferase Activity Drive a Cancer Stem Cell Pathway in Triple-Negative Breast Cancer

Investigators used chemical biology tools to track how a metabolite of glucose, GlcNAc, became linked to the transcriptional regulatory protein tet-methylcytosine dioxygenase 1 (TET1) as an O-linked N-acetylglucosamine (O-GlcNAc) post-translational modification in three TNBC cell lines.