Overexpression of Fatty Acid Synthase Attenuates Bleomycin Induced Lung Fibrosis by Restoring Mitochondrial Dysfunction in Mice

Researchers showed that fatty acid synthase (FASN) expression was significantly reduced in the lungs of idiopathic pulmonary fibrosis patients and bleomycin (BLM)-treated mice. Overexpression of FASN significantly inhibited BLM-induced alveolar epithelial cell death, which was significantly potentiated by FASN knockdown.