SLC35E1 Promotes Keratinocyte Proliferation in Psoriasis by Regulating Zinc Homeostasis

SLC35E1 deficiency inhibited keratinocyte proliferation in both mice and cultured cells. On a molecular level, SLC35E1 was found to regulate zinc ion concentrations and subcellular localization, while zinc ion chelation reversed the imiquimod-induced psoriatic phenotype in Slc35e1−/− mice.