Adhesion to Laminin-1 and Collagen IV Induces the Formation of Ca2+ Microdomains That Sensitize Mouse T Cells for Activation

Adhesion to the ECM proteins collagen IV and laminin-1 increased the number of Ca2+ microdomains in a manner dependent on the kinase FAK, phospholipase C, and all three inositol 1,4,5-trisphosphate receptor subtypes and promoted the nuclear translocation of the transcription factor NFAT-1.