Flt1 Produced by Lung Endothelial Cells Impairs ATII Cell Transdifferentiation and Repair in Pulmonary Fibrosis

Researchers showed that lung endothelial cells secreted angiocrine factors that regulate alveolar cell differentiation. They built on previous data on the anti-fibrotic microRNA-200c and identified the Vascular Endothelial Growth Factor receptor 1, also named Flt1, as its main functional target in endothelial cells.