Crosstalk between RNA m⁶A and DNA Methylation Regulates Transposable Element Chromatin Activation and Cell Fate in Human Pluripotent Stem Cells

Researchers developed a targeted proteomic proximity labeling approach to capture transposable element (TE)-associated proteins in hESCs. They found that the RNA N6-methyladenosine (m6A) reader, YTHDC2, occupied genomic loci of the primate-specific TE, LTR7/HERV-H.