Human Alveolar Hydrogels Promote Morphological and Transcriptional Differentiation in iPSC-Derived Alveolar Type 2 Epithelial Cells

As extracellular matrix (ECM) was recognized as a vital component in directing cellular function and differentiation, scientists sought to derive hydrogels from decellularized human lung alveolar-enriched ECM to provide an ex vivo model to characterize the role of physiologically relevant ECM on induced pluripotent stem cells phenotype.