EGFR-T790M Mutation Derived Interactome Rerouted EGFR Translocation Contributing to Gefitinib Resistance in Non-Small Cell Lung Cancer

To illuminate the molecular basis linking acquired mutation to tyrosine kinase inhibitor (TKI) resistancee, affinity purification coupled mass spectrometry was adopted to dissect epidermal growth factor receptor interactome in TKI-sensitive and -resistant NSCLC cells.