The E3 Ligase DTX2 Inhibits RUNX1 Function by Binding Its C-Terminus and Prevents the Growth of RUNX1-Dependent Leukemia Cells

Scientists examined whether DTX2 was involved in the regulation of RUNX1 using in vitro and ex vivo analyses. DTX2 bound to RUNX1 and other RUNX family members RUNX2 and RUNX3 through their C-terminal region.