Skin Mesenchymal Niches Maintain and Protect AML-Initiating Stem Cells

Scientists reported massive acute myeloid leukemia (AML) cell infiltration in the skin in a transplantation-induced MLL-AF9 AML mouse model. These AML cells could regenerate AML after transplantation. Prospective niche characterization revealed that skin harbored mesenchymal progenitor cells with a similar phenotype as BM mesenchymal stem cells.