Kinase-Independent Role of mTOR and On-/Off-Target Effects of an mTOR Kinase Inhibitor

Researchers employed an inducible kinase-inactive D2338A mTOR knock-in mouse model together with a mTOR conditional knockout model to assess the kinase-dependent/-independent function of mTOR in hematopoiesis and the on-/off-target effects of mTOR kinase inhibitor AZD2014.