Modifications of Lipid Pathways Restrict SARS-CoV-2 Propagation in Human Induced Pluripotent Stem Cell-Derived 3D Airway Organoids

The authors generated iPSC-derived airway organoids (AOs) that resembled the human native airway. They subjected iPSC-AOs to SARS-CoV-2 infection and investigated the treatment effect of lipid modifiers statin drugs.