Neuropeptide CGRP Promotes Immune Homeostasis of Bacterial Meningitis by Inducing MHC-II Ubiquitination Get Access Arrow

The effects of calcitonin gene-related peptide (CGRP) on bacterial meningitis (BM) and the underlying mechanisms were investigated in BM mice in vivo and macrophages in vitro. When the underlying mechanisms were investigated, researchers found that CGRP induced proteasome-dependent degradation of MHC-II in macrophages and then inhibits CD4+ T cell activation.