Premetastatic Niche Mimicking Bone-On-A-Chip: A Microfluidic Platform to Study Bone Metastasis in Cancer Patients

Photocrosslinkable gelatin methacrylate was used as a 3D culturing hydrogel to encapsulate cells, and circulate tumor culture medium adjacent to the hydrogel to verify the critical role of mesenchymal stem cells and osteoclasts.