Defective LAT Signalosome Pathology in Mice Mimics Human IgG4-Related Disease at Single-Cell Level

Mice with a loss-of-function mutation in the LAT adaptor (LatY136F) develop an autoimmune and type 2 inflammatory disorder called defective LAT signalosome pathology (DLSP). Researchers analyzed via single-cell omics the trajectory leading to LatY136F DLSP, and the underlying CD4+ T cell diversification.