Increased Hyaluronan by Naked Mole-Rat Has2 Improves Healthspan in Mice

The most notable change observed in mice overexpressing naked mole-rat hyaluronic acid synthase 2 gene was attenuated inflammation across multiple tissues. High-molecular-mass hyaluronic acid reduced inflammation through several pathways, including a direct immunoregulatory effect on immune cells, protection from oxidative stress, and improved gut barrier function during aging.