An mRNA-Based Broad-Spectrum Vaccine Candidate Confers Cross-Protection Against Heterosubtypic Influenza a Viruses

Investigators conceptualized a novel mRNA-based multi-antigen influenza vaccine consisting of three conserved antigens of influenza A virus, including the ectodomain of the M2 ion channel, the long alpha-helix of haemagglutinin stalk region, and nucleoprotein.