Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity

Using a novel enzymatic inhibitor of the RNA methyl­transferase METTL3, the authors demonstrated that a global decrease in N6-methyladenosine resulted in double-stranded RNA formation and a profound cell-intrinsic interferon response.
[Cancer Discovery]
AbstractPress Release

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