Preexisting Tumor-Resident T Cells with Cytotoxic Potential Associate with Response to Neoadjuvant Anti–PD-1 in Head and Neck Cancer

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Investigators identified reinvigoration of cytotoxicity among ZNF683+CD8+ T cells as a likely mechanism underlying response to neoadjuvant anti–PD-1 in head and neck cancer.
[Science Immunology]
Abstract