Therapy-Induced Senescence Contributes to the Efficacy of Abemaciclib in Patients With Dedifferentiated Liposarcoma

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The authors coordinated a first-in-kind Phase II clinical trial of the CDK4/6i abemaciclib for patients with progressive dedifferentiated liposarcoma with cellular studies interrogating the molecular basis of geroconversion.
[Clinical Cancer Research]
Abstract