Neddylation-Dependent LSD1 Destabilization Inhibits the Stemness and Chemoresistance of Gastric Cancer
Neural precursor cell-expressed developmentally down-regulated protein 8 was identified to be conjugated to lysine-specific demethylase 1 (LSD1) at K63 by ubiquitin-conjugating enzyme E2 M.
[International Journal of Biological Macromolecules]
[Cell Metabolism] Using exercise and sarcopenia models, mice lacking IL6Rα on T cells demonstrated deficits in regulatory T cells, their functional maturation, and a more pronounced decline in muscle mass.
[Communications Biology] Based on the up-regulation of catabolism and down-regulation of anabolism, researchers showed genetic mutation-mediated metabolic reprogramming in the progression of cancer cachexia by screening for metabolites and investigating their direct effect on muscle atrophy.
[Acta Pharmacologica Sinica] Researchers investigated the effect of myeloid-derived growth factor to postinjury neointimal formation and the underlying mechanisms. Rat carotid arteries balloon-injured model was established.