3D-Cultured Blastoids Model Human Embryogenesis from Pre-Implantation to Early Gastrulation Stages

Investigators reported that blastoids cultured on thick three-dimensional (3D) extracellular matrices captured hallmarks of early post-implantation development, including epiblast lumenogenesis, rapid expansion and diversification of trophoblast lineages, and robust invasion of extravillous trophoblast cells by day 14.