Grainyhead-Like 2 Is Required for Morphological Integrity of Mouse Embryonic Stem Cells and Orderly Formation of Inner Ear-Like Organoids

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The authors generated different homozygous deletions to knockout grainyhead-like 2 (Grhl2) in mouse embryonic stem cells, including some mimicking naturally occurring truncations in the dimerisation domain related to human deafness autosomal dominant type 28.
[Frontiers in Cell and Developmental Biology]
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