Grainyhead-Like 2 Is Required for Morphological Integrity of Mouse Embryonic Stem Cells and Orderly Formation of Inner Ear-Like Organoids

The authors generated different homozygous deletions to knockout grainyhead-like 2 (Grhl2) in mouse embryonic stem cells, including some mimicking naturally occurring truncations in the dimerisation domain related to human deafness autosomal dominant type 28.