Loss of Polarity Protein Par3 in the Intestinal Epithelium Promotes Colitis-Associated Colorectal Cancer Progression by Damaging Tight Junction Assembly

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To understand how partitioning defective 3 (Par3) is related to colorectal cancer (CRC), researchers investigated the role of Par3 in the development of CRC using an in vivo genetic approach.
[Molecular Carcinogenesis]
Abstract