CRNDE Mediated hnRNPA2B1 Stability Facilitates Nuclear Export and Translation of KRAS in Colorectal Cancer

Investigators found that the colorectal neoplasia differentially expressed (CRNDE)/heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2B1) axis was notably elevated in colorectal cancer (CRC) and was strongly associated with poor prognosis of patients, while also significantly promoting CRC cell proliferation and metastasis both in vitro and in vivo.