Tripartite Motif Containing 59 Mediates Protective Anti-oxidative Effects in Intestinal Injury Through Nrf2 Signaling

Scientists identified TRIM59 as a critical and novel endogenous suppressor of kelch-like ECH-associated protein 1 (KEAP1) and also determined that TRIM59 was a KEAP1-interacting partner protein that catalyzes its ubiquitination and degradation in intestinal epithelial cells.