Oncometabolite D-2-Hydroxyglutarate—Dependent Metabolic Reprogramming Induces Skeletal Muscle Atrophy during Cancer Cachexia

Based on the up-regulation of catabolism and down-regulation of anabolism, researchers showed genetic mutation-mediated metabolic reprogramming in the progression of cancer cachexia by screening for metabolites and investigating their direct effect on muscle atrophy.