Engineered Mesenchymal Stem Cell Exosomes Loaded with miR-34c-5p Selectively Promote Eradication of Acute Myeloid Leukemia Stem Cells

The authors employed simultaneous two-step modifications to engineer MSCs and MSC-derived exosomes to create exosomes overexpressing the fused protein lysosome-associated membrane protein 2-interleukin 3 and hematopoietic cell E-selectin/L-selectin ligand.