MYH10 Activation Rescues Contractile Defects in Arrhythmogenic Cardiomyopathy (ACM)

By studying pathogenic deletion mutations in the desmosomal protein plakophilin-2 (PKP2), investigators identified a general mechanism by which PKP2 delocalization restrictED actomyosin network organization and cardiac sarcomeric contraction in arrhythmogenic cardiomyopathy.