Alpha-1 Adrenergic Signaling Drives Cardiac Regeneration via Extracellular Matrix Remodeling Transcriptional Program in Zebrafish Macrophages

Genetic manipulation and single-cell transcriptomics showed that the receptor signals activation of an “extracellular matrix remodeling” transcriptional program in a macrophage subset, which served as a key regulator of matrix composition and turnover.